Leukadherin-1 | 2059

A novel small molecule agonist of integrin CD11b/CD18 (also known as Mac-1). LA1 increases the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils, which results in decreased chemotaxis and transendothelial migration. LA1 also decreases leukocyte recruitment and reduced arterial narrowing after injury in rats. In addition, compared to a known integrin antagonist IMB-10, LA1 better preserves kidney function in a mouse model of experimental nephritis.

Leukadherin-1 is a novel small molecule agonist of integrin CD11b/CD18 (also known as Mac-1). LA1 increases the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils, which results in decreased chemotaxis and transendothelial migration.

2059 | Leukadherin-1 DataSheet

Alternate Name/Synonyms: 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid; LA1

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 344897-95-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₂H₁₅NO₄S₂

Molecular Weight: 421.49

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO (10 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A small molecule agonist of integrin CD11b/CD18

MDL Number: N/A

PubChem CID: 5342077

SMILES: C1=CC=C(C=C1)CN2C(=O)C(=CC3=CC=C(O3)C4=CC=C(C=C4)C(=O)O)SC2=S

InChi: InChI=1S/C22H15NO4S2/c24-20-19(29-22(28)23(20)13-14-4-2-1-3-5-14)12-17-10-11-18(27-17)15-6-8-16(9-7-15)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-

InChi Key: AEZGRQSLKVNPCI-UNOMPAQXSA-N