LF3 | B2644

LF3 is a potent inhibitor of canonical Wnt signaling pathway (IC₅₀ < 2 µM ). It can disrupt the interaction between catenin and TCF4. LF3 blocks the expression of a series of Wnt target genes in Wnt-addicted colon cancer cells. It inhibits proliferation of Wnt-addicted colon cancer cells through induction of cell-cycle arrest and also inhibits self-renewal capacity of cancer stem cells (CSCs).

LF3 is a potent inhibitor of canonical Wnt signaling pathway (IC₅₀ < 2 µM ). It can disrupt the interaction between catenin and TCF4. LF3 blocks the expression of a series of Wnt target genes in Wnt-addicted colon cancer cells. It inhibits proliferation of Wnt-addicted colon cancer cells through induction of cell-cycle arrest and also inhibits self-renewal capacity of cancer stem cells (CSCs).

B2644 | LF3 DataSheet

Alternate Name/Synonyms: 1-Piperazinecarbothioamide, N-[4-(aminosulfonyl)phenyl]-4-(3-phenyl-2-propen-1-yl)-

Appearance: White to off-white solid

Formulation:

CAS Number: 664969-54-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₄N₄O₂S₂

Molecular Weight: 416.56

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and specific inhibitor of canonical Wnt signaling

MDL Number:

PubChem CID: 1213452

SMILES: C1CN(CCN1CC=CC2=CC=CC=C2)C(=S)NC3=CC=C(C=C3)S(=O)(=O)N

InChi: InChI=1S/C20H24N4O2S2/c21-28(25,26)19-10-8-18(9-11-19)22-20(27)24-15-13-23(14-16-24)12-4-7-17-5-2-1-3-6-17/h1-11H,12-16H2,(H,22,27)(H2,21,25,26)/b7-4+

InChi Key: ZUQIFHLBPBLRRM-QPJJXVBHSA-N