Licochalcone A | B1909

Licochalcone A is a natural chalcone isolated originally from roots and rhizomes of licorice (Glycyrrhiza spp.). It has anti-inflammatory properties, supporting its use as a skin lightening agent. Licochalcone A (10-50 µM) induces apoptosis and suppresses migration and invasion of cancer cells in vitro. Recently, Licochalcone A has been found to irreversibly inhibit CYP3A4 enzyme, a critical component of the cytochrome P450 (CYP) family.

Licochalcone A is a natural chalcone isolated originally from roots and rhizomes of licorice (Glycyrrhiza spp.). It has anti-inflammatory properties, supporting its use as a skin lightening agent. Licochalcone A (10-50 µM) induces apoptosis and suppresses migration and invasion of cancer cells in vitro. Recently, Licochalcone A has been found to irreversibly inhibit CYP3A4 enzyme, a critical component of the cytochrome P450 (CYP) family.

B1909 | Licochalcone A DataSheet

Alternate Name/Synonyms: (2E)-3-[5-(1,1-dimethyl-2-propen-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one

Appearance: Yellow solid

Formulation: N/A

CAS Number: 58749-22-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₂O₄

Molecular Weight: 338.39

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An anti-inflammatory agent and CYP3A4 inhibitor

MDL Number: MFCD01417903

PubChem CID: 5318998

SMILES: CC(C)(C=C)C1=C(C=C(C(=C1)C=CC(=O)C2=CC=C(C=C2)O)OC)O

InChi: InChI=1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+

InChi Key: KAZSKMJFUPEHHW-DHZHZOJOSA-N