LIMKi 3 | B1095

LIMKi 3 is a potent, and cell-permeable inhibitor of LIMK1 (IC₅₀ = 7 nM) and LIMK2 (IC₅₀ = 8 nM) and inhibits coflin phosphorylation in MDA-MB-231 breast cancer cells without affecting tubulin polymerization or inducing cytotoxicity. It also reduces MDA-MB-231 tumor cell invasion in a 3D matrigel invasion assay.

LIMKi 3 is a potent, and cell-permeable inhibitor of LIMK1 (IC₅₀ = 7 nM) and LIMK2 (IC₅₀ = 8 nM) and inhibits coflin phosphorylation in MDA-MB-231 breast cancer cells without affecting tubulin polymerization or inducing cytotoxicity. It also reduces MDA-MB-231 tumor cell invasion in a 3D matrigel invasion assay.

B1095 | LIMKi 3 DataSheet

Alternate Name/Synonyms: N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide ; BMS 5

Appearance: White Solid

Formulation: N/A

CAS Number: 1338247-35-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₄Cl₂F₂N₄OS

Molecular Weight: 431.29

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: LIMKi 3 is a potent inhibitor of LIMK1 and LIMK2

MDL Number: N/A

PubChem CID: 56965901

SMILES: CC(C)C(=O)NC1=NC=C(S1)C2=CC(=NN2C3=C(C=CC=C3Cl)Cl)C(F)F

InChi: InChI=1S/C17H14Cl2F2N4OS/c1-8(2)16(26)23-17-22-7-13(27-17)12-6-11(15(20)21)24-25(12)14-9(18)4-3-5-10(14)19/h3-8,15H,1-2H3,(H,22,23,26)

InChi Key: IVUGBSGLHRJSSP-UHFFFAOYSA-N