LIN28A Antibody| F40207-0.08ML/F40207-0.4ML/RQ5665

LIN28A Antibody| F40207-0.08ML/F40207-0.4ML/RQ5665 | Gentaur UK, US & Europe Distribution

Background: LIN28A is a translational enhancer that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits ZCCHC11/TUT4 uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation.[UniProt]

Format: Purified

Clone: 55CT58.12.1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Isotype: Mouse IgG1, k

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, IHC, IF, ELISA

Application Details: Western blot: 1:200-1:2000, IHC (Paraffin): 1:50-1:200, Immunofluorescence: 1:10-1:50

Application Note: Titration of the LIN28A antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This LIN28A antibody is available for research use only.

Purity: Purified

Immunogen: LIN28A recombinant protein was used to produce this monoclonal antibody.

Storage: Aliquot the LIN28A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A