Linagliptin | 2240

An antidiabetic agent. Acts as a potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that breaks down glucagon-like peptide 1 (GLP-1). Prevents the inactivation of endogenous GLP-1 and GIP through competitive inhibition of the DPP IV enzyme.

A potent dipeptidyl peptidase IV (DPP IV) inhibitor

2240 | Linagliptin DataSheet

Alternate Name/Synonyms: 8-[(3R)-3-aminopiperidin-1-yl]-7-(but-2-yn-1-yl)-3- methyl-1--[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione; BI-1356

Appearance: White to yellowish solid

Formulation: N/A

CAS Number: 668270-12-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₆N₈O₂

Molecular Weight: 472.54

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>15 mg/ml) or H₂O (<1 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent dipeptidyl peptidase IV (DPP IV) inhibitor

MDL Number: MFCD14635356

PubChem CID: 10096344

SMILES: CC#CCN1C2=C(N=C1N3CCCC(C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C

InChi: InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1

InChi Key: LTXREWYXXSTFRX-QGZVFWFLSA-N