Lipoma Preferred Partner Antibody | 36-343

Lipoma Preferred Partner Antibody | 36-343 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Pig, Rat

Homology: N/A

Immunogen: Recombinant human lipoma preferred partner (LPP) (aa 1-109) .

Research Area: Apoptosis, Cancer, Immunology

Tested Application: ICC, IP, WB

Application: Immunocytochemistry: (1:500) . Immunohistochemistry: (1:500) . Western Blot: (1:1, 000) . Optimal conditions must be determined individually for each application.

Specificiy: Recognizes human, rat and pig LPP.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: Antigen affinity purified.

Clonality: Polyclonal

Clone: N/A

Isotype: N/A

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Liquid. In PBS containing 0.01% sodium azide.

Concentration: 500 ug/ml

Storage Condition: Stable for at least 1 year after receipt when stored at -20˚C.

Alternate Name: LPP; LIM Domain-containing Preferred Translocation Partner in Lipoma

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Lipoma preferred partner (LPP) is encoded by the preferred fusion partner gene of the high mobility group protein HMGI-C. LPP is frequently affected by chromosomal translocations in a major group of soft tissue lipomas, as well as in a parosteal lipoma and in pulmonary chondroid hamartomas. The resulting fusion proteins comprise three DNA binding domains of HMGI-C fused to two or three C-terminal LIM domains of LPP and a reciprocal product, respectively. Expression of a HMGI-C/LPP fusion protein causes malignant transformation of fibroblasts. Similar to its relatives zyxin and TRIP (thyroid receptor interacting protein 6) / ZRP-1 (zyxin-related protein 1) , LPP consists of a N-terminal proline-rich domain followed by three C-terminal LIM domains (double zinc finger structures that are involved in protein-protein interactions) . Like the cytoskeletal protein zyxin, LPP localizes to focal adhesions and cell-cell adherens junctions. LPP harbors a nuclear export signal and displays transcriptional activation capacity.