Liproxstatin-1 | B2312

A potent inhibitor of ferroptosis. Liproxstatin-1 suppresses ferroptosis in human cells and in an ischemia/reperfusion-induced tissue injury model in mice. Knockout of glutathione peroxidase 4 (Gpx4) Has been shown to cause cell death by ferroptosis. Liproxstatin-1 was able to suppress ferroptosis in Gpx4 knock-out mice.

Liproxstatin-1 is a potent inhibitor of ferroptosis. Liproxstatin-1 suppresses ferroptosis in human cells and in an ischemia/reperfusion-induced tissue injury model in mice. Knockout of glutathione peroxidase 4 (Gpx4) Has been shown to cause cell death by ferroptosis. Liproxstatin-1 was able to suppress ferroptosis in Gpx4 knock-out mice.

B2312 | Liproxstatin-1 DataSheet

Alternate Name/Synonyms: N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine

Appearance: White to off-white solid

Formulation:

CAS Number: 950455-15-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₉H₂₁ClN₄

Molecular Weight: 340.85

Cell-Permeable?:

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A ferroptosis inhibitor

MDL Number:

PubChem CID: 20931416

SMILES: C1CNCCC12C(=NC3=CC=CC=C3N2)NCC4=CC(=CC=C4)Cl

InChi: InChI=1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)

InChi Key: YAFQFNOUYXZVPZ-UHFFFAOYSA-N