Lithocholic acid | 2187

Lithocholic acid (LCA) is a hydrophobic secondary bile acid that is primarily formed in the intestine by the bacterial 7-α dehydroxylation of chenodeoxycholic acid. Acts as a detergent to solubilize fats for absorption. Known to display both carcinogenic and apoptotic activities. Also binds to the p53 binding sites of both MDM2 and MDM4 with a five-fold preference for MDM4.

Lithocholic acid (LCA) is a hydrophobic secondary bile acid that acts as a detergent to solubilize fats for absorption. Known to display both carcinogenic and apoptotic activities. Also binds to the p53 binding sites of both MDM2 and MDM4 with a five-fold preference for MDM4.

2187 | Lithocholic acid DataSheet

Alternate Name/Synonyms: 3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol; LCA

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 434-13-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₄₀O₃

Molecular Weight: 376.57

Cell-Permeable?: No

Purity: ≥97% by TLC

Solubilities: DMSO or EtOH

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A detergent and an endogenous inhibitor of MDM2 and MDM4

MDL Number: MFCD00003682

PubChem CID: 9903

SMILES: CC(CCC(=O)O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C

InChi: InChI=1S/C24H40O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,25H,4-14H2,1-3H3,(H,26,27)/t15-,16-,17-,18+,19-,20+,21+,23+,24-/m1/s1

InChi Key: SMEROWZSTRWXGI-HVATVPOCSA-N