LM22B-10 | B3018

LM22B-10 is an activator of Tropomyosin-receptor kinase neurotrophin receptors TrkB and TrkC. It binds to TrkB and TrkC in a dose-dependent manner at concentrations of 250 nM-2000 nM. It increases cell survival and accelerates neurite outgrowth. LM22B-10 supports substantial early neurite outgrowth in the presence of inhibiting glycoproteins. In aged mice, it (50 mg/kg/day i.p. in combination with an intranasal dose of 5 mg/kg/day for 30 days) activates hippocampal and striatal TrkB and TrkC, their downstream signaling and increases hippocampal dendritic spine density.

LM22B-10 is an activator of Tropomyosin-receptor kinase neurotrophin receptors TrkB and TrkC. It binds to TrkB and TrkC in a dose-dependent manner at concentrations of 250 nM-2000 nM. It increases cell survival and accelerates neurite outgrowth. LM22B-10 supports substantial early neurite outgrowth in the presence of inhibiting glycoproteins. In aged mice, it (50 mg/kg/day i.p. in combination with an intranasal dose of 5 mg/kg/day for 30 days) activates hippocampal and striatal TrkB and TrkC, their downstream signaling and increases hippocampal dendritic spine density.

B3018 | LM22B-10 DataSheet

Alternate Name/Synonyms: 2-[4-[[4-[bis(2-hydroxyethyl)amino]phenyl]-(4-chlorophenyl)methyl]-N-(2-hydroxyethyl)anilino]ethanol; 4,4'-(4-Chlorobenzylidene)bis[N,N-bis(2-hydroxyethyl)aniline]; 2,2',2'',2'''-[[(4-chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakis-ethanol; 2,2',2'',2'''-((((4-chlorophenyl)methylene)bis(4,1-phenylene))bis(azanetriyl))tetraethanol

Appearance: Pale grey solid

Formulation:

CAS Number: 342777-54-2

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₇H₃₃ClN₂O₄

Molecular Weight: 485

Cell-Permeable?: TRUE

Purity: >98%

Solubilities: ~30 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An activator of Tropomyosin-receptor kinase neurotrophin receptors TrkB and TrkC

MDL Number: MFCD00005622

PubChem CID: 542158

SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)N(CCO)CCO)C3=CC=C(C=C3)Cl)N(CCO)CCO

InChi: InChI=1S/C27H33ClN2O4/c28-24-7-1-21(2-8-24)27(22-3-9-25(10-4-22)29(13-17-31)14-18-32)23-5-11-26(12-6-23)30(15-19-33)16-20-34/h1-12,27,31-34H,13-20H2

InChi Key: QCXQLSGBOUUVNH-UHFFFAOYSA-N