LOK Antibody (C-term E707) [APR17207G]

LOK Antibody (C-term E707) [APR17207G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This LOK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-721 amino acids from the C-terminal region of human LOK.

Cellular Localisation: Cell membrane; Peripheral membrane protein

Molecular Weight: 112135

Clone: Polyclonal

Gene Name: STK10

Gene ID: 6793

Function: Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.

Summary: Tissue Location: Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes) . Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Serine/threonine-protein kinase 10, Lymphocyte-oriented kinase, STK10, LOK