Lomeguatrib | 2224

Lomeguatrib is a potent inhibitor of DNA repair protein O6-Methylguanine-DNA methyltransferase (MGMT) and related mammalian proteins. PaTrin-2 displays nanomolar activity in vitro and in vivo.

Lomeguatrib is a potent inhibitor of DNA repair protein O6-Methylguanine-DNA methyltransferase (MGMT) and related mammalian proteins. PaTrin-2 displays nanomolar activity in vitro and in vivo.

2224 | Lomeguatrib DataSheet

Alternate Name/Synonyms: PaTrin-2; 6-​[(4-​bromo-​2-​thienyl)methoxy]-​9H-​purin-​2-​amine

Appearance: Off-white solid

Formulation: N/A

CAS Number: 192441-08-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₈BrN₅OS

Molecular Weight: 326.17

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mM)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent MGMT inhibitor

MDL Number: N/A

PubChem CID: 3025944

SMILES: C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N

InChi: InChI=1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)

InChi Key: JUJPKFNFCWJBCX-UHFFFAOYSA-N