Lonafarnib | B1616

Lonafarnib (SCH 66336) is a selectively farnesyltransferase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively.

Lonafarnib (SCH 66336) is a selectively farnesyltransferase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively.

B1616 | Lonafarnib DataSheet

Alternate Name/Synonyms: Sarasar; SCH 66336; SCH66336; SCH-66336, 4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-1-piperidinecarboxamide; farnesyltransferase inhibitor; FTI inhibitor

Appearance: Solid

Formulation: N/A

CAS Number: 193275-84-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₃₁Br₂ClN₄O₂

Molecular Weight: 638.82

Cell-Permeable?: Yes

Purity: 0.98

Solubilities: DMSO (127 mg/mL, 198.8 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective farnesyltransferase inhibitor

MDL Number: MFCD06795138

PubChem CID: 148195

SMILES: C1CN(CCC1CC(=O)N2CCC(CC2)C3C4=C(C=C(C=C4CCC5=CC(=CN=C35)Br)Cl)Br)C(=O)N

InChi: 1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1

InChi Key: DHMTURDWPRKSOA-RUZDIDTESA-N