Loperamide hydrochloride | 2683

Loperamide is an antidiarrheal agent that acts as a non-selective Ca²⁺ channel blocker. At nanomolar concentrations (Ki = 2 nM), Loperamide binds to µ-opioid receptors. Also acts as an mTOR-independent autophagy enhancer.

Loperamide is an antidiarrheal agent that acts as a non-selective Ca²⁺ channel blocker. At nanomolar concentrations (Ki = 2 nM), Loperamide binds to µ-opioid receptors. Also acts as an mTOR-independent autophagy enhancer.

2683 | Loperamide hydrochloride DataSheet

Alternate Name/Synonyms: 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide hydrochloride

Appearance: White solid

Formulation: N/A

CAS Number: 34552-83-5

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₃₃ClN₂O₂.HCl

Molecular Weight: 513.51

Cell-Permeable?: Yes

Purity: ≥98% by titration

Solubilities: DMSO (>20 mg/ml) or EtOH (>20 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A calcium channel blocker and an autophagy inducer

MDL Number: MFCD00058581

PubChem CID: 71420

SMILES: CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4.Cl

InChi: nChI=1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H

InChi Key: PGYPOBZJRVSMDS-UHFFFAOYSA-N