Loxoribine | 2003

A guanosine derivative that acts as a selective ligand for Toll-like receptor 7 (TLR7) via IFN. Activates natural killer cells and primes cytolytic precursor cells for activation by IL-2.

Loxoribine is a guanosine derivative that acts as a selective ligand for Toll-like receptor 7 (TLR7) via IFN. Activates natural killer cells and primes cytolytic precursor cells for activation by IL-2.

2003 | Loxoribine DataSheet

Alternate Name/Synonyms: 7-Allyl-8-oxoguanosine ; RWJ21757

Appearance: White solid

Formulation: N/A

CAS Number: 121288-39-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₇N₅O₆

Molecular Weight: 339.3

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO (30 mg/ml) or water (10 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A selective TLR7 ligand

MDL Number: MFCD00867591

PubChem CID: 60737

SMILES: C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O

InChi: InChI=1S/C13H17N5O6/c1-2-3-17-6-9(15-12(14)16-10(6)22)18(13(17)23)11-8 (21)7(20)5(4-19)24-11/h2,5,7-8,11,19-21H,1,3-4H2,(H3,14,15,16,22)/t5-, 7-,8-,11-/m1/s1

InChi Key: VDCRFBBZFHHYGT-IOSLPCCCSA-N