LP99 | B2853

LP99 is an inhibitor of BRD9 and BRD7 bromodomains. LP99 inhibits the interactions of both BRD7 and BRD9 with histones H3.3 and H4, with IC₅₀ values in the low micromolar range in bioluminescence resonance energy transfer (BRET) assays in HEK293 cells. It also inhibits IL-6 secretion from LPS stimulated THP-1 cells at a concentration of 10 μM.

LP99 is an inhibitor of BRD9 and BRD7 bromodomains. LP99 inhibits the interactions of both BRD7 and BRD9 with histones H3.3 and H4, with IC₅₀ values in the low micromolar range in bioluminescence resonance energy transfer (BRET) assays in HEK293 cells. It also inhibits IL-6 secretion from LPS stimulated THP-1 cells at a concentration of 10 μM.

B2853 | LP99 DataSheet

Alternate Name/Synonyms: N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxoquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamide; N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide

Appearance: A crystalline solid

Formulation:

CAS Number: 1808951-93-0

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₆H₃₀ClN₃O₄S

Molecular Weight: 516.05

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~20 mg/ml in ethanol, DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of BRD9 and BRD7 bromodomains

MDL Number:

PubChem CID: 91827372

SMILES: CC1=CC(=O)N(C2=C1C=CC(=C2)N3C(C(CCC3=O)NS(=O)(=O)CC(C)C)C4=CC=C(C=C4)Cl)C

InChi: InChI=1S/C26H30ClN3O4S/c1-16(2)15-35(33,34)28-22-11-12-24(31)30(26(22)18-5-7-19(27)8-6-18)20-9-10-21-17(3)13-25(32)29(4)23(21)14-20/h5-10,13-14,16,22,26,28H,11-12,15H2,1-4H3/t22-,26+/m0/s1

InChi Key: LVDRREOUMKACNJ-BKMJKUGQSA-N