LRIG1, Mouse Recombinant | P1557

LRIG1, also known as leucine-rich repeats and immunoglobulin-like domains 1 is a pan-negative regulator of the epidermal growth factor receptor (EGFR) signaling pathway. In studies with ErbB family members and Met kinase, LRIG regulates signaling by increasing ubiquitination and lysosomal degradation of the receptors. It functions as a tumor suppressor by controlling cell proliferation through the negative regulation of the EGF family of receptor tyrosine kinases. This protein expression, which is often dysregulated in human cancers, is a prognostic indicator of cancer development and relapse. Recombinant mouse LRIG1, fused to His-tag at Cterminus, was expressed in insect cell and purified by using conventional chromatography techniques.

P1557 | LRIG1, Mouse Recombinant DataSheet

Biomolecule/Target :

Synonyms: LIG-1, LIG1, leucine-rich repeats and immunoglobulin like domains 1, leucine rich repeats and immunoglobulin like domains 1

Alternates names: LIG-1, LIG1, leucine-rich repeats and immunoglobulin like domains 1, leucine rich repeats and immunoglobulin like domains 1

Taglines: Tumor suppressor, negative regulator of the EGF

NCBI Gene ID #: 16206

NCBI Gene Symbol: Lrig1

Gene Source: Mouse

Accession #: P70193

Recombinant: TRUE

Source: Baculovirus

Purity by SDS-PAGE: >90%

Assay: SDS - PAGE

Purity:

Assay #2:

Endotoxin Level: < 1 EU per 1 ug of protein (determined by LAL method)

Activity (Specifications/test method):

Biological activity:

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: 84.8 kDa (His-tag at C terminus)

Concentration: 0.5 mg/ml (determined by Bradford assay)

Appearance: Liquid

Physical form description: Liquid

Reconstitution Instructions:

Amino acid sequence: 770 aa (aa 35-796)

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans