LRP5 polyclonal Antibody | BS70101

LRP5 polyclonal Antibody | BS70101 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200

Background: LRP5 and LRP6 are single-pass transmembrane proteins belonging to the low-density lipoprotein receptor (LDLR) -related protein family. Unlike other members of the LDLR family, LRP5 and LRP6 have four EGF and three LDLR repeats in the extracellular domain, and proline-rich motifs in the cytoplasmic domain (1) . They function as co-receptors for Wnt and are required for the canonical Wnt/β-catenin signaling pathway (2,3) . LRP5 and LRP6 are highly homologous and have redundant roles during development (4,5) . The activity of LRP5 and LRP6 can be inhibited by the binding of some members of the Dickkopf (DKK) family of proteins (6,7) . Upon stimulation with Wnt, LRP6 is phosphorylated at multiple sites including Thr1479, Ser1490, and Thr1493 by kinases such as GSK-3 and CK1 (8-10) . Phosphorylated LRP6 recruits axin to the membrane and presumably activates β-catenin signaling (8-10) .LRP5 is involved in the regulation of bone homeostasis. Mutations and polymorphisms in LPR5 are associated with bone diseases like osteoporosis-pseudoglioma syndrome and high-bone-mass disorders (11-13) . In addition, mutations in LRP5 are found in patients with hyperparathyroid tumor and breast cancer (14,15) .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: LRP5 polyclonal Antibody detects endogenous levels of LRP5 protein.

Molecular Weight: ~ 150 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: LRP5;BMND1;EVR1;EVR4;HBM;LR3;LRP7;OPPG;OPS;OPTA1;VBCH2;

Immunogen: Recombinant protein of human LRP5.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: