LRRC8A Antibody | 8235

LRRC8A Antibody | 8235 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: LRRC8A antibody was raised against a 15 amino acid peptide near the amino terminus of human LRRC8A.
The immunogen is located within amino acids 60 - 110 of LRRC8A.

Research Area: Stem Cell, Signal Transduction

Tested Application: E, WB, IHC-P

Application: LRRC8A antibody can be used for detection of LRRC8A by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

Specificiy: LRRC8A antibody is human, mouse and rat reactive.

Positive Control 1: Cat. No. 1287 - EL4 Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 89 kDa
Observed: 95 kDa

Validation: N/A

Isoform: N/A

Purification: LRRC8A antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: LRRC8A antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: LRRC8A antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: Leucine rich repeat containing 8 family member A, leucine-rich repeat-containing protein 8A, LRRC8, AGM5

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The leucine rich repeat containing 8 family member A protein (LRRC8A) belongs the LRRC8 family of proteins within the LRR superfamily of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions (1, 2) . LRRC8A is a four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation (1) . LRRC8A has also been shown to be an essential component of the volume-regulated anion channel VRAC (3) .