LSM1 polyclonal Antibody | BS72419

LSM1 polyclonal Antibody | BS72419 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IHC

Application Range: WB 1:1000 - 1:3000 IHC 1:50 - 1:200

Background: Sm and Sm-like (LSm) proteins form donut-shaped heptameric complexes that are involved in various steps of RNA metabolism. LSm proteins facilitate RNA protein interactions and structural changes that are required during ribosomal subunit assembly. LSm1, also designated U6 snRNA-associated Sm-like protein or small nuclear ribonuclear CaSm, binds specifically to the 3'-terminal U-tract of U6 snRNA. Human LSm1 localizes to the cytoplasm in small, discrete foci. These foci are also the localization site for the mRNA decapping enzyme Dcp1/2 and the exonuclease Xm1. LSm1 is naturally overexpressed in pancreatic cancer as well as in certain breast cancer cell lines. The downregulation of LSm1 is involved in the progression of prostate cancer.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: LSM1 polyclonal Antibody detects endogenous levels of LSM1 protein.

Molecular Weight: ~ 17 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: U6 snRNA-associated Sm-like protein LSm1; Cancer-associated Sm-like; Small nuclear ribonuclear CaSm; CASM

Immunogen: Recombinant protein of human LSM1

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Histone Lysine Methylation Pathway,Examples of Crosstalk Between Post-translational Modifications,DNA Methylation,