LSN-2814617 | B2345

LSN-2814617 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM). It acts as a potent and selective potentiator of human and rat mGlu₅ receptors in vitro, displaying curve shift ratios of two to three fold in the concentration-response relationship to glutamate or the glutamate receptor agonist, DHPG, with no detectable intrinsic agonist properties.

LSN-2814617 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM). It acts as a potent and selective potentiator of human and rat mGlu₅ receptors in vitro, displaying curve shift ratios of two to three fold in the concentration-response relationship to glutamate or the glutamate receptor agonist, DHPG, with no detectable intrinsic agonist properties.

B2345 | LSN-2814617 DataSheet

Alternate Name/Synonyms: LSN2814617,5-[(7S)-3-tert-butyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-3-(4-fluorophenyl)-1,2,4-oxadiazole

Appearance: Crystalline solid

Formulation:

CAS Number: 1313498-08-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₈H₂₀FN₅O

Molecular Weight: 341.39

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: In DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective positive allosteric modulator at the mGlu5 receptor

MDL Number:

PubChem CID: 67300245

SMILES: CC(C)(C)C1=NN=C2N1CCC(C2)C3=NC(=NO3)C4=CC=C(C=C4)F

InChi: InChI=1S/C18H20FN5O/c1-18(2,3)17-22-21-14-10-12(8-9-24(14)17)16-20-15(23-25-16)11-4-6-13(19)7-5-11/h4-7,12H,8-10H2,1-3H3

InChi Key: NPRJTKMKUYJGAL-UHFFFAOYSA-N