Lubiprostone | B1319

Lubiprostone is a bicyclic fatty acid metabolite analog of Prostaglandin E1 that activates ClC-2 and CFTR chloride channels. It has been suggested that lubiprostone opens CFTR or both CFTR and ClC-2 through interactions with the prostaglandin receptor EP4.

Lubiprostone is a bicyclic fatty acid metabolite analog of Prostaglandin E1 that activates ClC-2 and CFTR chloride channels. It has been suggested that lubiprostone opens CFTR or both CFTR and ClC-2 through interactions with the prostaglandin receptor EP4.

B1319 | Lubiprostone DataSheet

Alternate Name/Synonyms: (11a,15R)-11,15-Epoxy-16,16-difluoro-15-hydroxy-9-oxo-prostan-1-oic acid, Ru 0211, Spi 0211

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 136790-76-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₃₂F₂O₅

Molecular Weight: 390.46

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: Lubiprostone is a bicyclic fatty acid metabolite analog of Prostaglandin E1 that activates ClC-2 and CFTR chloride channels.

MDL Number: N/A

PubChem CID: 157920

SMILES: CCCCC(C1(CCC2C(O1)CC(=O)C2CCCCCCC(=O)O)O)(F)F

InChi: InChI=1S/C20H32F2O5/c1-2-3-11-19(21,22)20(26)12-10-15-14(16(23)13-17(15)27-20)8-6-4-5-7-9-18(24)25/h14-15,17,26H,2-13H2,1H3,(H,24,25)/t14-,15-,17-,20-/m1/s1

InChi Key: WGFOBBZOWHGYQH-MXHNKVEKSA-N