LW6 | B2277

LW6 is a potent HIF-1 inhibitor (IC₅₀ = 4.4 μM). It promotes proteasomal degradation of HIF-1α via upregulation of von-Hippel-Landau (VHL) without affecting the activity of prolyl hydroxylase (PHD).

LW6 is a potent HIF-1 inhibitor (IC₅₀ = 4.4 μM). It promotes proteasomal degradation of HIF-1α via upregulation of von-Hippel-Landau (VHL) without affecting the activity of prolyl hydroxylase (PHD).

B2277 | LW6 DataSheet

Alternate Name/Synonyms: 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]-benzoic acid, methyl ester; CAY10585

Appearance: Off-white solid

Formulation: N/A

CAS Number: 934593-90-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₉NO₅

Molecular Weight: 435.51

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent HIF-1 inhibitor (I

MDL Number: N/A

PubChem CID: 16124726

SMILES: COC(=O)C1=CC(=C(C=C1)O)NC(=O)COC2=CC=C(C=C2)C34CC5CC(C3)CC(C5)C4

InChi: InChI=1S/C26H29NO5/c1-31-25(30)19-2-7-23(28)22(11-19)27-24(29)15-32-21-5-3-20(4-6-21)26-12-16-8-17(13-26)10-18(9-16)14-26/h2-7,11,16-18,28H,8-10,12-15H2,1H3,(H,27,29)

InChi Key: BJRPPNOJYFZSLY-UHFFFAOYSA-N