LXR-623 | B2454

LXR-623 is a potent and selective LXR (liver X receptor) agonist. Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and ABCG1 mRNA levels in rat peripheral blood cells. Orally bioavailable.

LXR-623 is a potent and selective LXR (liver X receptor) agonist. Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and ABCG1 mRNA levels in rat peripheral blood cells. Orally bioavailable.

B2454 | LXR-623 DataSheet

Alternate Name/Synonyms: WAY-252623; 2-(2-chloro-4-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole; WAY252623; LXR623

Appearance: White solid

Formulation:

CAS Number: 875787-07-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₂ClF₅N₂

Molecular Weight: 422.78

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >40 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective LXR modulator

MDL Number:

PubChem CID: 16734800

SMILES: C1=CC2=C(N(N=C2C(=C1)C(F)(F)F)CC3=C(C=C(C=C3)F)Cl)C4=CC=C(C=C4)F

InChi: InChI=1S/C21H12ClF5N2/c22-18-10-15(24)9-6-13(18)11-29-20(12-4-7-14(23)8-5-12)16-2-1-3-17(19(16)28-29)21(25,26)27/h1-10H,11H2

InChi Key: KYWWJENKIMRJBI-UHFFFAOYSA-N