LY-2584702 | 9445

LY-2584702 is a potent, ATP-competitive inhibitor of p70S6K signaling, with potential antineoplastic activity. LY-2584702 inhibits ribosomal protein S6 Kinase (p70S6K), and prevents phosphorylation of the S6 subunit of ribosomes, thereby inhibiting normal ribosomal function within tumor cells leading to a decrease in protein synthesis and in cellular proliferation.

LY-2584702 is a potent, ATP-competitive inhibitor of p70S6K signaling, with potential antineoplastic activity. LY-2584702 inhibits ribosomal protein S6 Kinase (p70S6K), and prevents phosphorylation of the S6 subunit of ribosomes, thereby inhibiting normal ribosomal function within tumor cells leading to a decrease in protein synthesis and in cellular proliferation.

9445 | LY-2584702 DataSheet

Alternate Name/Synonyms: 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-imidazol-2-yl]-1-piperidyl]-1H-pyrazolo[3,4-d]pyrimidine

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1082949-68-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₈H₂₇F₄N₇O₃S

Molecular Weight: 617.62

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An ATP-competitive inhibitor of p70S6K signaling

MDL Number: N/A

PubChem CID: 46205871

SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.CN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=NN4)C5=CC(=C(C=C5)F)C(F)(F)F

InChi: InChI=1S/C21H19F4N7.C7H8O3S/c1-31-10-17(13-2-3-16(22)15(8-13)21(23,24)25)29-19(31)12-4-6-32(7-5-12)20-14-9-28-30-18(14)26-11-27-20;1-6-2-4-7(5-3-6)11(8,9)10/h2-3,8-12H,4-7H2,1H3,(H,26,27,28,30);2-5H,1H3,(H,8,9,10)

InChi Key: HDYUXDNMHBQKAU-UHFFFAOYSA-N