LY-2603618 | B2191

LY-2603618 is a potent, selective and ATP-dependent inhibitor of checkpoint kinase 1 (Chk1) (IC₅₀ = 7 nM). It inhibits Chk1 autophosphorylation and increase DNA damage-mediated Chk1 phosphorylation. Displays antitumor activities.

LY-2603618 is a potent, selective and ATP-dependent inhibitor of checkpoint kinase 1 (Chk1) (IC₅₀ = 7 nM). It inhibits Chk1 autophosphorylation and increase DNA damage-mediated Chk1 phosphorylation. Displays antitumor activities.

B2191 | LY-2603618 DataSheet

Alternate Name/Synonyms: (S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea; Rabusertib

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 911222-45-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₂BrN₅O₃

Molecular Weight: 436.3

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, selective and ATP-dependent inhibitor of checkpoint kinase 1 (Chk1)

MDL Number: N/A

PubChem CID: 11955855

SMILES: CC1=CC(=C(C=C1Br)NC(=O)NC2=NC=C(N=C2)C)OCC3CNCCO3

InChi: InChI=1S/C18H22BrN5O3/c1-11-5-16(27-10-13-8-20-3-4-26-13)15(6-14(11)19)23-18(25)24-17-9-21-12(2)7-22-17/h5-7,9,13,20H,3-4,8,10H2,1-2H3,(H2,22,23,24,25)/t13-/m0/s1

InChi Key: SYYBDNPGDKKJDU-ZDUSSCGKSA-N