LY-2784544 | B1914

LY2784544 is a potent, selective and ATP-competitive JAK2 inhibitor (IC₅₀ = 3 nM). effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. LY2784544 effectively inhibits JAK2V617F-driven signaling and cell proliferation in Ba/F3 cells (IC₅₀= 20 and 55 nM, respectively). In comparison, LY2784544 is much less potent at inhibiting interleukin-3-stimulated wild-type JAK2-mediated signaling and cell proliferation (IC₅₀ = 1183 and 1309 nM, respectively).

LY2784544 is a potent, selective and ATP-competitive JAK2 inhibitor (IC₅₀ = 3 nM). effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. LY2784544 effectively inhibits JAK2V617F-driven signaling and cell proliferation in Ba/F3 cells (IC₅₀= 20 and 55 nM, respectively). In comparison, LY2784544 is much less potent at inhibiting interleukin-3-stimulated wild-type JAK2-mediated signaling and cell proliferation (IC₅₀ = 1183 and 1309 nM, respectively).

B1914 | LY-2784544 DataSheet

Alternate Name/Synonyms: Gandotinib

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1229236-86-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₅ClFN₇O

Molecular Weight: 469.94

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, selective and ATP-competitive JAK2 inhibitor

MDL Number: N/A

PubChem CID: 46213929

SMILES: CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F

InChi: InChI=1S/C23H25ClFN7O/c1-14-9-21(29-28-14)27-22-11-17(13-31-5-7-33-8-6-31)23-26-15(2)20(32(23)30-22)10-16-3-4-18(24)12-19(16)25/h3-4,9,11-12H,5-8,10,13H2,1-2H3,(H2,27,28,29,30)

InChi Key: SQSZANZGUXWJEA-UHFFFAOYSA-N