LY-333,531 hydrochloride | 2156

An isozyme-selective inhibitor of protein kinase Cβ (PKCβ). Inhibits both the PKCβI (IC₅₀ = 4.7 nM) and PKCβII (IC₅₀ = 5.9 nM) isozymes. LY-333,531 is 76- and 61-fold more selective for inhibition of PKCβI and PKCβII over PKCα.

LY-333,531 hydrochloride is an isozyme-selective inhibitor of protein kinase Cβ (PKCβ). Inhibits both the PKCβI (IC₅₀ = 4.7 nM) and PKCβII (IC₅₀ = 5.9 nM) isozymes. LY-333,531 is 76- and 61-fold more selective for inhibition of PKCβI and PKCβII over PKCα.

Alternate Name/Synonyms: Ruboxistaurin

Appearance: Red solid

Formulation: N/A

CAS Number: 169939-93-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₂₉ClN₄O₃

Molecular Weight: 505.01

Cell-Permeable?: Yes

Purity: ≥98% by NMR

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A protein kinase Cβ inhibitor

MDL Number: MFCD08702685

PubChem CID: 9870785

SMILES: CN(C)CC1CCN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCO1)C6=CC=CC=C65)C(=O)NC4=O.Cl

InChi: InChI=1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1

InChi Key: NYQIEYDJYFVLPO-FERBBOLQSA-N