LY-3381916 | B2729

LY-3381916 is a potent, selective and brain permeant IDO1 (Indoleamine 2,3-Dioxygenase1) inhibitor. LY-3381916 specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the amino acid tryptophan into the immunosuppressive metabolite kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, LY3381916 restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs).

LY-3381916 is a potent, selective and brain permeant IDO1 (Indoleamine 2,3-Dioxygenase1) inhibitor.

B2729 | LY-3381916 DataSheet

Alternate Name/Synonyms: (R)-4-fluoro-N-(1-(1-(tetrahydro-2H-pyran-4-carbonyl)indolin-5-yl)ethyl)benzamide,IDO1IN5,LY 3381916,IDO1-IN-5

Appearance: Crystalline solid

Formulation:

CAS Number: 2166616-75-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₅FN₂O₃

Molecular Weight: 396.46

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >100 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent, brain-permeant IDO1 inhibitor

MDL Number:

PubChem CID:

SMILES: FC1=CC=C(C(N[C@H](C)C2=CC=C(N(C(C3CCOCC3)=O)CC4)C4=C2)=O)C=C1

InChi: InChI=1S/C23H25FN2O3/c1-15(25-22(27)16-2-5-20(24)6-3-16)18-4-7-21-19(14-18)8-11-26(21)23(28)17-9-12-29-13-10-17/h2-7,14-15,17H,8-13H2,1H3,(H,25,27)/t15-/m1/s1

InChi Key: NUBWFWVVKLRSHS-OAHLLOKOSA-N