LY-341495 | 2875

LY341495 is a potent, brain-permeable, and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC₅₀s = 21 and 14 nM, respectively, for human isoforms). It less effectively blocks mGluR8 and mGluR7 (IC₅₀s = 173 and 990 nM, respectively) and weakly antagonizes mGluR1, mGluR5, and mGluR4 (IC₅₀s = 6.8, 8.2, and 22 μM, respectively).

LY341495 is a potent, brain-permeable, and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC₅₀s = 21 and 14 nM, respectively, for human isoforms). It less effectively blocks mGluR8 and mGluR7 (IC₅₀s = 173 and 990 nM, respectively) and weakly antagonizes mGluR1, mGluR5, and mGluR4 (IC₅₀s = 6.8, 8.2, and 22 μM, respectively).

2875 | LY-341495 DataSheet

Alternate Name/Synonyms: 2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid

Appearance: Off-white solid

Formulation: N/A

CAS Number: 201943-63-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₉NO₅

Molecular Weight: 353.37

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 3 mg/ml with slight warming)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A highly potent and selective group II metabotropic glutamate receptor antagonist

MDL Number: MFCD00949707

PubChem CID: 9819927

SMILES: C1C(C1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O

InChi: InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1

InChi Key: VLZBRVJVCCNPRJ-KPHUOKFYSA-N