LY2886721 | 2299

Cell-permeable. A potent and selective β-secretase (BACE-1) inhibitor (IC₅₀ = 20 nM for recombinant hBACE1). Does not inhibit other aspartyl proteases such as cathepsin D, pepsin, and renin. A potential agent to treat Alzheimer’s Disease.

LY2886721 is a potent and selective β-secretase (BACE-1) inhibitor (IC₅₀ = 20 nM for recombinant hBACE1

2299 | LY2886721 DataSheet

Alternate Name/Synonyms: N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide

Appearance: White solid

Formulation: N/A

CAS Number: 1262036-50-9

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₁₈H₁₆F₂N₄O₂S

Molecular Weight: 390.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml) or Ethanol (<1 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent selective β-secretase (BACE-1) inhibitor.

MDL Number: N/A

PubChem CID: 49837968

SMILES: C1C2CSC(=NC2(CO1)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)F)F)N

InChi: InChI=1S/C18H16F2N4O2S/c19-11-1-4-15(22-6-11)16(25)23-12-2-3-14(20)13(5-12)18-9-26-7-10(18)8-27-17(21)24-18/h1-6,10H,7-9H2,(H2,21,24)(H,23,25)/t10-,18-/m0/s1

InChi Key: NIDRNVHMMDAAIK-YPMLDQLKSA-N