M CD31 Antibody (C-term) [APR03495G]

M CD31 Antibody (C-term) [APR03495G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: Ha, M

Specificity: This Mouse CD31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-536 amino acids from the C-terminal region of mouse CD31.

Cellular Localisation: Cell membrane {ECO:0000250|UniProtKB:P16284}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P16284} Membrane raft {ECO:0000250|UniProtKB:P16284}. Cell junction {ECO:0000250|UniProtKB:P16284}. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation {ECO:0000250|UniProtKB:P16284}

Molecular Weight: 81263

Clone: Polyclonal

Gene Name: Pecam1

Gene ID: 18613

Function: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (By similarity) . Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (By similarity) . Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (By similarity) . Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (By similarity) . Homophilic ligation of PECAM1 prevents macrophage- mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (By similarity) . Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (By similarity) . Modulates bradykinin receptor BDKRB2 activation (By similarity) . Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (By similarity) . Induces susceptibility to atherosclerosis (PubMed:19048083) .

Summary: Tissue Location: Isoform 1 and isoform 3 are expressed in lung and platelets.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: FC--1:25 WB--1:2000

Synonyms: Platelet endothelial cell adhesion molecule, PECAM-1, CD31, Pecam1, Pecam, Pecam-1