Macrosphelide A | B3227

Macrosphelide A is a macrolide antibiotic. It inhibits adhesion of HL-60 human leukemia cells to human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner. It inhibits the growth of some ascomycetes, basidiomycetes, oomycetes and gram-positive bacteria, including the medically important Staphylococcus aureus (IC50 of ≤500 μg/ml in agar-based tests). Ineffective against yeasts and gram-negative bacteria when tested at concentrations up to 700 μg/ml.

Macrosphelide A is a macrolide antibiotic. It inhibits adhesion of HL-60 human leukemia cells to human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner. It inhibits the growth of some ascomycetes, basidiomycetes, oomycetes and gram-positive bacteria, including the medically important Staphylococcus aureus (IC50 of ≤500 μg/ml in agar-based tests). Ineffective against yeasts and gram-negative bacteria when tested at concentrations up to 700 μg/ml.

B3227 | Macrosphelide A DataSheet

Alternate Name/Synonyms: 9R,15R-dihydroxy-4S,10S,16S-trimethyl-1,5,11-trioxacyclohexadeca-7E,13E-diene-2,6,12-trione

Appearance: Lyophilized solid

Formulation:

CAS Number: 172923-77-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₂₂O₈

Molecular Weight: 342.4

Cell-Permeable?: TRUE

Purity: ≥95%

Solubilities: DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: Cell-cell adhesion inhibitor

MDL Number:

PubChem CID: 71433929

SMILES: O=C(O[C@@H](C)[C@H](O)/C=C/C1=O)C[C@H](C)OC(/C=C/[C@@H](O)[C@H](C)O1)=O

InChi: InChI=1S/C16H22O8/c1-9-8-16(21)24-11(3)13(18)5-7-15(20)23-10(2)12(17)4-6-14(19)22-9/h4-7,9-13,17-18H,8H2,1-3H3/b6-4+,7-5+/t9-,10-,11-,12+,13+/m0/s1

InChi Key: MJMMUATWVTYSFD-FTXQSDARSA-N