Maduramicin Ammonium | B3022

Maduramicin is a natural polyether ionophore antibiotic first isolated from the actinomycete Actinomadura rubra. It is commonly used in veterinary medicine as an anti-coccidial agent. It is cytotoxic against Cryptosporidium parvum infection in Swiss mice at a dosage of 1-2.5 mg/kg body weight. Maduramicin has an EC₅₀ of 14.8 nM against late-stage gametocyte viability and significantly blocks in vivo transmission in a mouse model of malaria transmission.

Maduramicin is a natural polyether ionophore antibiotic first isolated from the actinomycete Actinomadura rubra. It is commonly used in veterinary medicine as an anti-coccidial agent. It is cytotoxic against Cryptosporidium parvum infection in Swiss mice at a dosage of 1-2.5 mg/kg body weight. Maduramicin has an EC₅₀ of 14.8 nM against late-stage gametocyte viability and significantly blocks in vivo transmission in a mouse model of malaria transmission.

B3022 | Maduramicin Ammonium DataSheet

Alternate Name/Synonyms: azane,2-[(2R,3S,4S,5R,6S)-6-[(1R)-1-[(2S,5R,7S,8R,9S)-2-[(2R,5S)-5-[(2R,3S,5R)-3-[(2R,4S,5S,6S)-4,5-dimethoxy-6-methyloxan-2-yl]oxy-5-[(2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyloxan-2-yl]oxolan-2-yl]-5-methyloxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]ethyl]-2-hydroxy-4,5-dimethoxy-3-methyloxan-2-yl]acetic acid; Cygro; Maduramicin ammonium; Cygro; Prinicin ammonium

Appearance: White powder

Formulation:

CAS Number: 84878-61-5

Structure Available?: TRUE

Peptide sequence:

Salt Form: TRUE

Molecular Formula: C₄₇H₈₃NO₁₇

Molecular Weight: 934.16

Cell-Permeable?: TRUE

Purity: >95%

Solubilities: Soluble in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An ionophore antibiotic

MDL Number: MFCD00865282

PubChem CID: 68595

SMILES: CC1CC(C(OC1C2CC(C(O2)C3(CCC(O3)C4(CCC5(O4)CC(C(C(O5)C(C)C6C(C(C(C(O6)(CC(=O)O)O)C)OC)OC)C)O)C)C)OC7CC(C(C(O7)C)OC)OC)(C)O)C.N

InChi: InChI=1S/C47H80O17.H3N/c1-23-18-24(2)45(9,51)61-36(23)31-19-32(58-35-20-30(53-10)40(55-12)28(6)57-35)42(59-31)44(8)15-14-33(60-44)43(7)16-17-46(64-43)21-29(48)25(3)37(62-46)26(4)38-41(56-13)39(54-11)27(5)47(52,63-38)22-34(49)50;/h23-33,35-42,48,51-52H,14-22H2,1-13H3,(H,49,50);1H3/t23-,24+,25+,26+,27-,28-,29-,30-,31+,32-,33+,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46+,47+;/m0./s1

InChi Key: WQGJEAMPBSZCIF-HKSLRPGUSA-N