MALT1 Antibody | 8097

MALT1 Antibody | 8097 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: MALT1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MALT1.
The immunogen is located within amino acids 630 - 680 of MALT1.

Research Area: Cancer, Immunology

Tested Application: E, WB, IHC-P, IF

Application: MALT1 antibody can be used for detection of MALT1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: MALT1 antibody is human, mouse and rat reactive. At least two isoforms of MALT1 are known to exist; this antibody will detect both isoforms.

Positive Control 1: Cat. No. 1287 - EL4 Cell Lysate

Positive Control 2: Cat. No. 10-901 - Human Spleen Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 91 kDa
Observed: 96 kDa

Validation: N/A

Isoform: N/A

Purification: MALT1 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: MALT1 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: MALT1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: Mucosa associated lymphoid tissue lymphoma translocation 1, IMD12, MLT, MLT1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: MALT1 was initially identified as a novel gene that was recurrently rearranged in t (11;18) (q21;q21) mucosa-associated lymphoid tissue lymphomas along with the apoptosis inhibitor protein c-IAP2 (1) . MALT1, along with the proteins CARMA1 and Bcl10 form an NF-kappaB-activating complex, termed the CBM signalsome, that acts downstream of lymphocyte antigen receptors as well as many other non-lymphoid cell-surface receptors that play a role in multiple cellular functions (2, 3) . MALT1 has proteolytic activity, and this activity is critical for full NF-kappaB response in T cell activation (4) .