MALT1 Inhibitor, MI-2 | B2368

MALT1 inhibitor MI-2 is a potent inhibitor of the paracaspase MALT1 (Mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1) (IC₅₀ = 5.84 μM). MI-2 binds directly to MALT1 and irreversibly suppresses protease function. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.

MALT1 inhibitor MI-2 is a potent inhibitor of the paracaspase MALT1 (Mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1) (IC₅₀ = 5.84 μM). MI-2 binds directly to MALT1 and irreversibly suppresses protease function. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.

B2368 | MALT1 Inhibitor, MI-2 DataSheet

Alternate Name/Synonyms: MI-2,2-chloro-N-(4-(5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl)phenyl)acetamide

Appearance: Off-white solid

Formulation:

CAS Number: 1047953-91-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₉H₁₇Cl₃N₄O₃

Molecular Weight: 455.72

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >5 mg/ml (EtOH) in 0,>40 mg/ml (DMSO) in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent MALT1 inhibitor

MDL Number:

PubChem CID: 45942672

SMILES: COCCOC1=NN(C(=N1)C2=CC(=C(C=C2)Cl)Cl)C3=CC=C(C=C3)NC(=O)CCl

InChi: InChI=1S/C19H17Cl3N4O3/c1-28-8-9-29-19-24-18(12-2-7-15(21)16(22)10-12)26(25-19)14-5-3-13(4-6-14)23-17(27)11-20/h2-7,10H,8-9,11H2,1H3,(H,23,27)

InChi Key: TWJGQZBSEMDPQP-UHFFFAOYSA-N