MASP1 (HC) polyclonal Antibody | BS7033

MASP1 (HC) polyclonal Antibody | BS7033 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, three types of MBL-associated serine proteases, MASP-1, MASP-2 and MASP-3, and a truncated form of MASP-2 (small MBL-associated protein; sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system. MASP-3 is an alternatively spliced product from the MASP-1 gene. The heavy/A chains are identical between MASP-1 and MASP-3 but the light/B chains are entirely different. Activated MASPs subsequently cleave and activate downstream components of the complement pathway.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MASP-1 (HC) polyclonal Antibody detects endogenous levels of Mannan-binding lectin serine protease 1 heavy chain.

Molecular Weight: ~ 47 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Mannan-binding lectin serine protease 1; Complement factor MASP-3; Mannose-binding lectin-associated serine protease 1; MASP-1; Ra-reactive factor serine protease p100; RaRF; Serine protease 5; Mannan-binding lectin serine protease 1 heavy chain; MASP1; CRARF; CRARF1; PRSS5

Immunogen: Recombinant full length Human MASP1 heavy chain.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A