MAT1A polyclonal Antibody | BS8325

MAT1A polyclonal Antibody | BS8325 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200

Background: Methionine adenosyltransferase (MAT) catalyzes the formation of S-adenosyltransferase (AdoMet) for methionine catabolism in the liver. Two different genes, MAT1A and MAT2A, encode a liver specific and non-liver specific form of MAT, designated MAT Iα and MAT IIα, respectively. Inactivation of the liver specific gene product, designated MAT I/III, associates with liver diseases such as cirrhosis. MAT Iα expression also correlates with a differentiated phenotype, whereas liver cells expressing MAT IIα present a dedifferentiated phenotype and lowered AdoMet synthesis. Likewise, NF-kB and TNFα cause a switch from MAT Iα to MAT IIα expression in human hepatocellular carcinoma (HCC), which facilitates cancer cell growth.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MAT1A polyclonal Antibody detects endogenous levels of MAT1A protein.

Molecular Weight: ~ 44 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: S-adenosylmethionine synthase isoform type-1; AdoMet synthase 1; Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/III; MAT1A; AMS1; MATA1

Immunogen: Recombinant full length Human MAT1A.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: