MCM9 Antibody (C-term) [APR04542G]

MCM9 Antibody (C-term) [APR04542G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This MCM9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 316-345 amino acids from the C-terminal region of human MCM9.

Cellular Localisation: Nucleus. Chromosome. Note=Colocalizes to nuclear foci with RPA1 following DNA damage (PubMed:23401855) . Localizes to double- stranded DNA breaks (PubMed:23401855) . Recruited to chromatin by MSH2 (PubMed:26300262) .

Molecular Weight: 127313

Clone: Polyclonal

Gene Name: MCM9

Gene ID: 254394

Function: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross- links (ICLs) by homologous recombination (HR) (PubMed:23401855) . Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093) . Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855) . Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262) . In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262) . The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855) . Probably by regulating HR, plays a key role during gametogenesis (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: DNA helicase MCM9, hMCM9, Mini-chromosome maintenance deficient domain-containing protein 1, Minichromosome maintenance 9, MCM9, C6orf61, MCMDC1