MDM4 Polyclonal Antibody | E-AB-67135

MDM4 Polyclonal Antibody | E-AB-67135 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: MDM4, HDMX, MDMX, MRP1

Application: WB

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism

Background: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: A synthetic peptide of human MDM4

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:500-1:1000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 13 kDa/14 kDa/18 kDa/49 kDa/54 kDa

Molecular Weight(Observed): 47 kDa