MEF-2 (phospho-T312) polyclonal Antibody | BS4120

MEF-2 (phospho-T312) polyclonal Antibody | BS4120 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC IP

Application Range: IHC: 1:50~1:200 IP: 1:10~1:100

Background: The myocyte enhancer factor-2 (MEF-2) family of transcription factors associated with co-repessors or co-activators to regulate development and function of T cells, neuronal cells and muscle cells. Four family members arise from alternatively spliced transcripts, termed MEF-2A, -2B, -2C and -2D. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-MEF-2 (T312) polyclonal Antibody detects endogenous levels of MEF-2 protein only when phosphorylated at Thr312

Molecular Weight: ~ 55 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Myocyte-specific enhancer factor 2A; Serum response factor-like protein 1; MEF2A; MEF2

Immunogen: Synthetic phosphopeptide derived from human MEF-2 around the phosphorylation site of Threonine 312.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Warburg Effect,G Protein-coupled Receptors Signaling to MAPK Erk,