MEK-4/ MAP2K4 (phospho-S80) polyclonal Antibody | BS4167

MEK-4/ MAP2K4 (phospho-S80) polyclonal Antibody | BS4167 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK 5, whereas MEK-6 phosphorylates p38 and p38β. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-MEK-4/ MAP2K4 (S80) polyclonal Antibody detects endogenous levels of MEK-4 protein only when phosphorylated at Ser80.

Molecular Weight: ~ 44 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKK; MAP2K4; JNKK1; MEK4; MKK4;; PRKMK4; SEK1; SERK1; SKK1

Immunogen: Synthetic phosphopeptide derived from human MEK-4 around the phosphorylation site of Serine 80.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: SAPK JNK Signaling Cascades,Signaling Pathways Activating p38 MAP KinaseMAPK Erk in Growth and Differentiation Pathway,