MEK-7  (phospho-S271)  polyclonal Antibody | BS4906

MEK-7  (phospho-S271)  polyclonal Antibody | BS4906 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat,Mouse

Application: WB

Application Range: WB: 1:500~1:1000

Background: MKK7 is a MAP kinase kinase that serves as a specific activator of the SAPK/JNK pathway. MKK7 is strongly activated by TNF-α, as well as other environmental stresses, whereas SEK1/MKK4, which activates both p38 and SAPK/JNK pathways, is not activated by TNF-α. Sequence alignment of the activation loop of the MAP kinase kinase family members indicates that Ser271 and Thr275 are potential phosphorylation sites that are crucial for the kinase acivity.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MEK-7  (phospho-S271)  polyclonal Antibody detects endogenous levels of MEK-7 protein only when phosphorylated at Ser271.

Molecular Weight: ~ 48 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Mitogen Activated Protein Kinase kinase 7; c-Jun N-terminal kinase kinase 2; JNK activating kinase 2; Jnkk 2; Jnkk2; MAP2K7; MAPKK-7; MKK 7; MKK-7; PRKMK 7; PRKMK7; Sek-2; Dual specificity mitogen activated protein kinase kinase 7; JNK kinase 2; Jnkk

Immunogen: Synthetic phosphopeptide derived from human MEK-7 around the phosphorylation site of Serine 271

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: