METTL1 Antibody (Center) [APR32746G]

METTL1 Antibody (Center) [APR32746G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This METTL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the Central region of human METTL1.

Cellular Localisation: Nucleus

Molecular Weight: 31471

Clone: Polyclonal

Gene Name: METTL1 {ECO:0000255|HAMAP-Rule:MF_03055, ECO:0000312|HGNC:HGNC:7030}

Gene ID: 4234

Function: Methyltransferase that mediates the formation of N (7) - methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083) . Catalyzes the formation of N (7) -methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084) . Also acts as a methyltransferase for a subset of internal N (7) -methylguanine in mRNAs (PubMed:31031084) . Internal N (7) -methylguanine methylation of mRNAs regulates translation (PubMed:31031084) . Also methylates a specific subset of miRNAs, such as let-7 (PubMed:31031083) . N (7) -methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (PubMed:31031083) . Acts as a regulator of embryonic stem cell self-renewal and differentiation (By similarity) .

Summary: Tissue Location: Ubiquitous..

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: tRNA (guanine-N (7) -) -methyltransferase {ECO:0000255|HAMAP-Rule:MF_03055}, 21133 {ECO:0000255|HAMAP-Rule:MF_03055}, Methyltransferase-like protein 1 {ECO:0000255|HAMAP-Rule:MF_03055}, tRNA (guanine (46) -N (7) ) -methyltransferase {ECO:0000255|HAMAP-Rule:MF_03055}, tRNA (m7G46) -methyltransferase {ECO:0000255|HAMAP-Rule:MF_03055}, METTL1 {ECO:0000255|HAMAP-Rule:MF_03055}, C12orf1