MG-115 | 1831

A potent, reversible proteasome inhibitor with Ki of 21 nM for 20S proteasome and 35 nM for 26S proteasome. The inhibition of proteasome was through specific inhibition of chymotrypsin-like activity of the proteasome. Also shown to induce apoptosis in Rat-1 and PC12 cells via a p3-independent pathway.

MG-115 is a potent, reversible proteasome inhibitor with Ki of 21 nM for 20S proteasome and 35 nM for 26S proteasome. The inhibition of proteasome was through specific inhibition of chymotrypsin-like activity of the proteasome. Also shown to induce apoptosis in Rat-1 and PC12 cells via a p3-independent pathway.

1831 | MG-115 DataSheet

Alternate Name/Synonyms: Z-LL-NVa-CHO; Z-Leu-Leu-Nva-CHO

Appearance: White to off-white solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: Z-Leu-Leu-Leu-Nva-CHO

Salt Form: No

Molecular Formula: C₂₅H₃₉N₃O₅

Molecular Weight: 461.59

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A proteasome inhibitor

MDL Number: MFCD00671410

PubChem CID: 9868928

SMILES: CCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1

InChi: InChI=1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1

InChi Key: QEJRGURBLQWEOU-FKBYEOEOSA-N