MI-3 | B1834

MI-3 is a Menin-MLL (Mixed linage leukemia) protein interaction inhibitor with an IC₅₀ of 648 ± 25 nM. MLL protein is a histone methyltransferase that positively regulates gene transcription. However, MLL gene is a common target for chromosomal translocations found in some leukemia.

MI-3 is a Menin-MLL (Mixed linage leukemia) protein interaction inhibitor with an IC₅₀ of 648 ± 25 nM. MLL protein is a histone methyltransferase that positively regulates gene transcription. However, MLL gene is a common target for chromosomal translocations found in some leukemia.

B1834 | MI-3 DataSheet

Alternate Name/Synonyms: 4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine; Menin-MLL inhibitor 3

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1271738-59-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₈H₂₅N₅S₂

Molecular Weight: 375.55

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Menin-MLL (Mixed linage leukemia) protein interaction inhibitor

MDL Number: N/A

PubChem CID: 71651135

SMILES: CC(C)C1=NC(=C2C=CSC2=N1)N3CCN(CC3)C4=NCC(S4)(C)C

InChi: InChI=1S/C18H25N5S2/c1-12(2)14-20-15(13-5-10-24-16(13)21-14)22-6-8-23(9-7-22)17-19-11-18(3,4)25-17/h5,10,12H,6-9,11H2,1-4H3

InChi Key: BYEYBIAXHABAEB-UHFFFAOYSA-N