MI-463 | B2668

MI-463 is a potent inhibitor of Menin-MLL interaction (IC₅₀ = 15.3 nM). Pharmacologic inhibition of the menin-mLL interaction substantially delays progression of mLL leukemia in murine models through on-target activity without causing toxicity. MI-463 induces strong inhibition of tumor growth with once daily intraperitoneal administration.

MI-463 is a potent inhibitor of Menin-MLL interaction (IC₅₀ = 15.3 nM). Pharmacologic inhibition of the menin-mLL interaction substantially delays progression of mLL leukemia in murine models through on-target activity without causing toxicity. MI-463 induces strong inhibition of tumor growth with once daily intraperitoneal administration.

B2668 | MI-463 DataSheet

Alternate Name/Synonyms: 4-methyl-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile, MI463

Appearance: Crystalline solid

Formulation:

CAS Number: 1628317-18-9

Structure Available?: Yes

Peptide sequence:

Salt Form: No

Molecular Formula: C₂₄H₂₃F₃N₆S

Molecular Weight: 484.55

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent inhibitor of Menin-MLL interaction

MDL Number: MFCD28506301

PubChem CID: 90455046

SMILES: CC1=C(C=CC2=C1C=C(N2)C#N)CN3CCC(CC3)NC4=C5C=C(SC5=NC=N4)CC(F)(F)F

InChi: InChI=1S/C24H23F3N6S/c1-14-15(2-3-21-19(14)8-17(11-28)31-21)12-33-6-4-16(5-7-33)32-22-20-9-18(10-24(25,26)27)34-23(20)30-13-29-22/h2-3,8-9,13,16,31H,4-7,10,12H2,1H3,(H,29,30,32)

InChi Key: DZACSLYTXLZAAF-UHFFFAOYSA-N