MI-nc (hydrochloride) | B2816

MI-nc (hydrochloride) is a weak inhibitor of the menin-MLL interaction. Menin is a tumor suppressor protein. Menin is a part of the MLL (Mixed Lineage Leukemia) SET1-like histone methyl transferase complex. Association of menin with MLL fusion proteins causes oncogenic transformation. MI-nc (hydrochloride) showed very weak inhibition of the menin-MLL interaction (IC₅₀ = 193 μM) in vitro. It serves as a negative control for MI-2 which is a potent menin-MLL interaction inhibitor (IC₅₀ = 0.45 μM).

MI-nc (hydrochloride) is a weak inhibitor of the menin-MLL interaction. Menin is a tumor suppressor protein. Menin is a part of the MLL (Mixed Lineage Leukemia) SET1-like histone methyl transferase complex. Association of menin with MLL fusion proteins causes oncogenic transformation. MI-nc (hydrochloride) showed very weak inhibition of the menin-MLL interaction (IC₅₀ = 193 μM) in vitro. It serves as a negative control for MI-2 which is a potent menin-MLL interaction inhibitor (IC₅₀ = 0.45 μM).

B2816 | MI-nc (hydrochloride) DataSheet

Alternate Name/Synonyms: MI-nc, 6-ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]-thieno[2,3-d]pyrimidine,dihydrochloride

Appearance: Crystalline solid

Formulation:

CAS Number: 1934302-23-4

Structure Available?: True

Peptide sequence:

Salt Form: True

Molecular Formula: C₁₄H₁₈Cl₂N₆S₂

Molecular Weight: 405.36

Cell-Permeable?: True

Purity: ≥98%

Solubilities: 0.1 mg/ml in in Ethanol, 1.3 mg/ml in in DMSO, 0.16 mg/ml in PBS, pH 7.2 in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A weak inhibitor of the menin-MLL interaction

MDL Number:

PubChem CID: 132989422

SMILES: CCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NN=CS4.Cl.Cl

InChi: 1S/C14H16N6S2.2ClH/c1-2-10-7-11-12(15-8-16-13(11)22-10)19-3-5-20(6-4-19)14-18-17-9-21-14;;/h7-9H,2-6H2,1H3;2*1H

InChi Key: QFOIGNCIUPMVOO-UHFFFAOYSA-N