Milrinone | 2163

Cell-permeable. A potent, cAMP-specific phosphodiesterase (PDEIII ) inhibitor (IC₅₀ = 0.45 and 1.0 µM for PDEIIIA and PDEIIIB, respectively). It inhibits other PDE isoforms at much higher concentrations. Milrinone has positive inotropic (stimulates cardiac muscle contractions) and vasodilatory effects when administered in vivo.

Milrinone is a potent, cAMP-specific phosphodiesterase (PDEIII ) inhibitor (IC₅₀ = 0.45 and 1.0 µM for PDEIIIA and PDEIIIB, respectively). It inhibits other PDE isoforms at much higher concentrations. Milrinone has positive inotropic (stimulates cardiac muscle contractions) and vasodilatory effects when administered in vivo.

2163 | Milrinone DataSheet

Alternate Name/Synonyms: 1,​6-​dihydro-​2-​methyl-​6-​oxo-​[3,​4'-​bipyridine]-​5-​carbonitrile; WIN 47, 203

Appearance: Off-white solid

Formulation: N/A

CAS Number: 78415-72-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₉N₃O

Molecular Weight: 211.22

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A cAMP-specific phosphodiesterase (PDEIII ) inhibitor

MDL Number: MFCD00133539

PubChem CID: 4197

SMILES: CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2

InChi: InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)

InChi Key: PZRHRDRVRGEVNW-UHFFFAOYSA-N