Mitoxantrone | 1885

An anti-tumor antibiotic and type II topoisomerase inhibitor. It disrupts DNA synthesis and DNA repair in both healthy and cancer cells. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells.

Mitoxantrone is an anti-tumor antibiotic and type II topoisomerase inhibitor. It disrupts DNA synthesis and DNA repair in both healthy and cancer cells.

1885 | Mitoxantrone DataSheet

Alternate Name/Synonyms: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione

Appearance: Dark blue soild

Formulation: N/A

CAS Number: 65271-80-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₈N₄O₆

Molecular Weight: 444.48

Cell-Permeable?: No

Purity: ≥98%

Solubilities: DMSO (~88 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A topoisomerase II inhibitor

MDL Number: MFCD00242942

PubChem CID: 4212

SMILES: C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO

InChi: InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2

InChi Key: KKZJGLLVHKMTCM-UHFFFAOYSA-N